Kate White Lab
multi-scale cellular mapping
Structural Cell mapping
Many questions remain on how the structure and function of proteins, complexes, organelles, and cells are coordinated during normal cellular functions and how this is disrupted in disease. My goal is to help bridge the gap between structural biology and physiology by pioneering new experimental and computational tools for multi-scale structural biology (atomic to cellular scales).
Challenge of spatial and temporal scales in cell mapping
Mapping the beta cell
We use pancreatic ß-cells as a model system to:
determine the role of distinct micro-environments in subcellular neighborhoods on protein structure and function
determine the role of insulinotropic drugs (compounds that stimulate insulin synthesis and secretion) in cellular rearrangements, including organelle-organelle interactions and trafficking
develop new methods and infrastructure to support community engagement in whole-cell modeling