Cell Mapping Manuscripts

28. Loconte V and White KL. The use of soft X-ray tomography to explore mitochondrial structure and function. Molecular Metabolism. (2022). PMID: 35148829. DOI:10.1016/j.molmet.2021.101421

27. Loconte V, Singla J, Li A, Chen J-H, Ekman A, McDermott G, Sali A, White KL*, Larabell CA*. Soft X-ray tomography to map and quantify organelle interactions at the mesoscale. Structure. (2022). PMID: 35148829

26. Singla J, Burdsall K, Cantrell B, Halsey JR, McDowell A, McGregor C, Stevens RC, Su S, Thomopoulos A, Vaillant T, White KL, Zhang B, Berman H. A new visual design language for biological structures in a cell. Structure (2022). DOI:10.1016/j.str.2022.01.002

25. Singla J and White KL. A community approach to whole-cell modeling. (2021). Current Opinion in Systems Biology. 26:33-38. DOI:10.1016/j.coisb.2021.03.009.

24. Raveh B*, Sun L*, White KL*, Sanyal T*, Barath K, Tempkin J, Liu J, Zheng DQ, Bharat, K, Singla J, Wang C, Zhao J, Li A, Francis JP, Graham NA, Kesselman C, Stevens RC, Sali A. Bayesian metamodeling complex biological systems across varying representations. (2021). PNAS (35):e2104559118. PMID: 34453000

23. Wang Z, Gurlo T, Wang P, Rosenberger M, Junge J, Stevens RC, White KL, Fraser SE, Butler PC. Live cell imaging of glucose impact on beta and alpha cell metabolism in health and type 2 diabetes. (2021). Communications Biology (4): 594. PMID: 34012065

22. Singla J, White KL, Stevens RC, Alber F. Assessment of scoring functions to rank the quality of 3D subtomogram clusters from cryo-electron tomography. (2021). J Struct Biol. PMID: 33753204

21. White KL, Singla J, Loconte V, Chen J-H, Ekman A, Francis JP, Sun L, Zhang X, Francis JP, Li A, Lin W, Tseng K, McDermott G, Alber F, Sali A, Larabell C, Stevens RC. Visualizing subcellular rearrangements in intact β-cells using soft X-ray tomography. (2020) Science Advances (6): eabc8262.

20. Zhang X, Carter SD, Singla J, White KL, Butler PC, Stevens RC, Jensen GJ. Visualizing insulin vesicle neighborhoods in beta-cells by cryo-electron tomography. (2020) Science Advances (6): eabc8258.

19. Francis JP, Wang H, White KL, Syeda-Mahmood T, Stevens RC. Neural Network Segmentation of Cell Ultrastructure Using Incomplete Annotation. IEEE International Symposium on Biomedical Imaging (2020) DOI:10.1109/ISBI45749.2020.9098739

18. Berman HM, Adams PD, Bonvin AA, Burley SK, Carragher B, Chiu W, DiMaio F, Ferrin TE, Gabanyi MJ, Goddard TD, Griffin PR, Haas J, Hanke CA, Hock JC, Hummer G, Kurisu G, Lawson CL, Leitner A, Markley JL, Meiler J, Montelione GT, Phillips GN, Prisner T, Rappsilber J, Schriemer DC, Schwede T, Seidel CAM, Strutzenberg TS, Svergun DI, Tajkhorshid E, Trewhella J, Vallat B, Velankar S, Vuister GW, Webb B, Westbrook JD, White KL, Sali A. Federating structural models and data: outcomes from a workshop on archiving integrative structures. (2019) Structure, 27(2):1745-1759.

17. Singla J*, McClary K*, White KL*, Alber F, Sali A, Stevens RC. Opportunities and challenges in building a spatiotemporal multi-scale model of the human pancreatic β-cell. (2018) Cell. 173(1):11-19.

Prior GPCR Structure and Function Studies

16. Lamichhane R, Liu JJ, White KL, Katritch V, Stevens RC, Wuthrich K, Millar D. Biased signaling of the G protein-coupled receptor β2AR is governed by conformational exchange kinetics. (2020) Structure. 28(3):371-377.

15. Claff T, Yu J, Blais V, Patel N, Martin C, Wu L, Han GW, Holleran BJ, Van der Poorten O, White KL, Hanson MA, Sarret P, Gendron L, Cherezov V, Katritch V, Ballet S, Liu Z-J, Muller CE, Stevens RC. Elucidating the active delta-opioid receptor crystal structure with peptide and small molecule agonists. (2019) Science Advances. 5(11).

14. Gutierrez MG, Deyell J, White KL, Dalle Ore LC, Cherezov V, Stevens RC, Malmstadt N. The lipid phase preference of the adenosine A2A receptor depends on its ligand binding state. (2019) Chemical Communications, 55: 5724-5727.

13. Audet M, White KL, Breton B, Zarzycka B, Lu Y, Gati C, Batyuk A, Popov P, Han GW, Velasquez J, Manahan D, Hanson M, Shui W, Katrich V, Cherezov V, Stevens RC. Crystal structure of active prostaglandin E2 receptor 3 bound to a prostaglandin analogue. (2019) Nature Chemical Biology, 15: 11-17.(Cover of Nat Chem Biol)

12. Eddy MT, Lee M-Y, Gao Z-G, White KL, Didenko T, Horst R, Audet M, Stanczak P, McClary KM, Han GW, Jacobson KA, Stevens RC, Wuthrich K. Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2AAdenosine Receptor (2018) Cell. 172(1-2):68-80.

11. White KL*, Eddy MT*, Gao ZG, Han GW, Lian T, Deary A, Jacobson KA, Stevens RC. Structural connection between activation microswitch and allosteric sodium site in GPCR signaling. (2018) Structure. 26(2):259-269. (Cover of Structure)

10. Zhang H, Han GW, Batyuk A, Ishchenko A, White KL, Patel N, Sadybekov A, Zamlynny B, Rudd MT, Hollenstein K, Tolstikova A, White TA, Hunter MS, Weierstall U, Liu W, Baboaglu K, Moore EL, Katz RD, Shipman JM, Garcia-Calvo M, Sharma S, Sheth P, Soisson SM, Stevens RC, Katritch V, Cherezov V. Structural basis for selectivity and diversity in angiotensin II receptors. (2017) Nature.544(7650):327-332.

9. Farrell MS, McCorvy JD, Huang X.P., Urban DJ, White KL, Giguere PM, Doak A, Bernstein AI, Stout KA, Park SM, Rodriguiz RM, Gray BW, Hyatt W.S., Norwood A.P., Webster K, Gannon BM, Miller GW, Porter JH, Shoichett B, Fantegrossi WE, Roth BL. In vitro and in vivo characterization of the alkaloid nuciferine. (2016) PLoS One. 11(3):e0150602.

8. Lamichhane R, Liu JJ, Pljevaljcic G, White KL, van der Schans E, Katritch V, Stevens RC, Wuthrich K, Millar DP. Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor β2AR. (2015) Proc Natl Acad Sci USA. 112(38):11852-7.

7. O’Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wuthrich K, Milon. NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor. (2015) Proc Natl Acad Sci USA. 112(38):11852-7.

6. Robinson JE, Vardy E, DiBerto JF, Chefer VI, White KL, Fish EW, Chen M, Gigante E, Krouse MC, Sun H, Thorsell A, Roth BL, Heilig M, Malanga CJ. Receptor reserve moderates mesolimbic responses to opioid in a humanized mouse model of the OPRM1 A118G polymorphism. (2015) Neuropsychopharmacology. 40(11):2614-22.

5. Vardy E, Robinson JE, Li C, Olsen RHJ, DiBerto JF, Giguere PM, Sassano FM, Huang XP, Zhu H, Urban DJ, White KL, Rittiner JE, Crowley NA, Pleil KE, Mazzone CM, Mosier PD, Song J, Kash TL, Malanga CJ, Krashes MJ, Roth BL. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. (2015) Neuron. 86(4):936-46. Highlighted in F1000 as “very good.”

4. White KL, Robinson EJ, Zhu H, Diberto JF, Polepally PR, Zjawiony JK, Nichols DE, Malanga CJ, Roth BL. The G-protein biased kappa opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivo. (2015) Journal of Pharmacology and Experimental Therapeutics. 352(1):98-109. Highlighted in F1000 as“exceptional.”

3. White KL, Scopton AP, Rives M.-L., Bikbulatov RV, Polepally PR, Brown PJ, Kenakin T, Javitch JA, Zjawiony JK, Roth BL. Identification of novel functionally selective kappa opioid receptor scaffolds. (2014) Molecular Pharmacology. 85(1):83-90

2. Polepally PR, White KL, Vardy E, Roth BL, Ferreira D, Zjawiony JK. Kappa-opioid receptor-selective dicarboxylicester-derived salvinorin A ligands (2013). Bioorganic & Medicinal Chemistry Letters. 23(10):2869-2

1. White KL and Roth BL. Psychotomimetic Effects of Kappa Opioid Receptors. (2012) Biological Psychiatry. 72(10):797-8